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4SC

Becoming a dermato-oncology expert

Outlook | Pharmaceutical & healthcare | 30 Oct 2017

4SC's new core strategy revealed earlier this year has focused on dermato-oncological indications, while its assets for other indications are partnered. The sharp focus will allow 4SC to become an expert in the field and to accumulate commercial know-how, as the company intends to market the core assets (resminostat, 4SC-202 and 4SC-208) in orphan indications on its own. A successful fund-raise in July means that the company now has sufficient funds until 2020 and past several important R&D events. We have overhauled our model to reflect 4SC's new strategy and our new valuation is €344m or €11.2/share.

4SC

Increased focus on core business

Update | Pharmaceutical & healthcare | 19 May 2016

4SC's Q1 results highlight an increased focus on its core business of epigenetic research and commercialisation, resulting from the sale of the operational assets (for €650k in proceeds) of its discovery and collaborative segment, 4SC Discovery. 2016 is an important year for 4SC with expected newsflow from its clinical pipeline including the launch of its potentially pivotal EU Phase II study with resminostat in Cutaneous T-cell lymphoma (CTCL) and expected Phase II Japanese trial data in HCC and NSCLC (from partner Yakult).

4SC

Steady R&D newsflow

Update | Pharmaceutical & healthcare | 09 Feb 2018

Over the past several months 4SC has reported progress with both its clinical-stage assets – resminostat and 4SC-202. The pivotal trial with resminostat as a maintenance therapy in advanced CTCL passed the first DSMB review and is on track to report data in H119. The Phase Ib/II study with 4SC-202 for melanoma has been initiated, while another Phase II study with 4SC-202 for GI cancer should start in Q118. 4SC-208 completes the core portfolio and is expected to enter the clinic in early 2019. Our valuation is largely unchanged at EUR 347m or EUR 11.3/share (EUR 344m previously).

4SC

Executive interview - 4SC

Edison TV: | Pharmaceutical & healthcare | 10 Aug 2017

4SC is a Munich-based cancer biopharmaceutical company. In this interview Jason Loveridge, CEO of 4SC, provides an overview of the company, its recent equity capital raise (€41m gross) and its updated and progressive development plan.

4SC

Intention to raise equity to progress development

Update | Pharmaceutical & healthcare | 17 May 2017

4SC has announced an updated development programme, to be funded by an equity fund-raising, which we expect in 2017. The proceeds from this will be used to accelerate development of 4SC's leading drug candidates. This will include continuing to progress resminostat in CTCL (initiated at end 2016), a subsequent filing of a marketing authorisation application in Europe (2019) and progression of resminostat into a further pivotal study in HCC (2018). 4SC also expects a pivotal study in 4SC-202 in Merkel cell carcinoma (2018) and the progression of 4SC-208 into clinical evaluation (early 2019). Our forecasts and valuation are under review. We believe that if 4SC executes the proposed plans it could be a significant and positive step.

4SC

A streamlined focus moving forward

Update | Pharmaceutical & healthcare | 30 Mar 2017

2016 was an important year for 4SC as it launched its potentially pivotal Phase II study with resminostat, an epigenetic cancer drug, in CTCL. In addition, it announced positive subgroup analysis of a Phase II study in HCC with its partner Yakult. It is streamlining its focus on three core assets: resminostat, 4SC-202 (initiating Phase II trials in 2017) and 4SC-208 (initiating preclinical development). We have slightly increased our rNPV to €124m, but note that we forecast a cash horizon to end 2017/early 2018.

4SC

First patient enrolled in pivotal RESMAIN study

Update | Pharmaceutical & healthcare | 19 Dec 2016

4SC has announced the enrolment of the first patient in its RESMAIN study. This is a pivotal study to evaluate resminostat (RES), an epigenetic cancer drug for maintenance treatment (MAIN) in patients with advanced-stage cutaneous T-cell lymphoma (CTCL). We expect early data to be reported in 2019. We increase our rNPV to EUR 120m from EUR 117m as we have raised the probability of the CTCL programme in Europe to 30% (from 20%) following the initiation of the trial.

4SC

Positive detailed analysis of Phase II trial data

QuickView | Pharmaceutical & healthcare | 09 Nov 2016

4SC has announced positive Phase II results from a more detailed analysis of the HCC Yakult Phase II trial data, which we believe could lead to further clinical development. It has also recently announced the sale of its immunology portfolio (Vidofludimus and a cytokine inhibitor), which further streamlines the company's focus on its core business of epigenetics while retaining potential upside (via milestones and royalties). We increase our rNPV to €117m from €110m to reflect the increase in the potential of resminostat development in Japan.

4SC

Positive detailed analysis of Phase II trial data

Update | Pharmaceutical & healthcare | 06 Oct 2016

4SC has announced positive Phase II results from a more detailed analysis of the HCC Yakult Phase II trial data, which we believe could lead to further clinical development. It has also recently announced the sale of its immunology portfolio (Vidofludimus and a cytokine inhibitor), which further streamlines the company's focus further on its core business of epigenetics while retaining potential upside (via milestones and royalties). We increase our rNPV to €117m from €110m to reflect the increase in potential of resminostat development in Japan.

4SC

Focus on Phase II CTCL launch, Q416

Update | Pharmaceutical & healthcare | 15 Aug 2016

H1 results were in line with our expectations and primarily underscored the potential importance of more detailed analysis of the Phase II Yakult Phase I/II trial data (expected early 2017) and the launch of its potentially pivotal Phase II study with resminostat in CTCL (Q416). 4SC is also progressing its earlier-stage assets such as 4SC-205, being developed in China with partner Link Health, and indicates that it is actively pursuing a partner for 4SC-202. We slightly raise our rNPV to €110m.

4SC

Core focus on track despite disappointing results

Update | Pharmaceutical & healthcare | 13 Jun 2016

4SC has announced that its partner Yakult Honsha did not reach the primary endpoint in its Asian liver cancer trial with all-comer patients. As a result, it will not be progressing resminostat to a pivotal study. These results do not affect 4SC's core focus on the launch of its pivotal EU Phase II resminostat study in CTCL and progression of its earlier pipeline. A positive partnership with Link Health (4SC-205) and data at ASCO (4SC-202) underline this. Removal of the Japan HCC contribution reduces our rNPV to €104m (vs €145m).

4SC

Important progression of clinical pipeline in 2016

Update | Pharmaceutical & healthcare | 01 Apr 2016

2016 is an important year for 4SC as it will launch its potentially pivotal Phase II study with resminostat, an epigenetic cancer drug, in CTCL. In addition, we expect partner Yakult to report Phase II Japanese trial data in HCC and NSCLC. Alongside its primary focus on resminostat for CTCL, 4SC is actively pursuing partnerships for its earlier stage assets, 4SC-202 and 4SC-205, which would enable both candidates to move into Phase II. We maintain our rNPV at €143m, with near-term potential catalysts.